Experience Betterbase – a revolutionary enhancement buffer meticulously crafted by Microzone. With precision and clarity at its core, Betterbase is the embodiment of innovation. Purposefully designed for ABI BigDye v1.1 and v3.1 sequencing mixes, it’s a game-changer that promotes simplicity, ensuring you achieve flawless sequencing, every single time.

  • State-of-the-art enhancing buffer tailored for ABI BigDye sequencing mixes
  • Universal compatibility: Suits all sequencing machines with unrivaled efficiency
  • Designed to replace both commercial and home-made dilution buffers
  • Distinctive formulation to amplify results, even from the most challenging templates


  • Promises amplified accuracy, especially with challenging templates
  • Drives cost-effectiveness, By diluting your BigDye™ you’ll save on overheads
  • Increases signal and reads
  • Simple to use
  • Dilution of ABI BigDye™ V1.1 and V3.1
  • Sanger Sequencing
  • Use with ABI, MegaBACE and Beckman instrumentation

Microzone’s BetterBase was released not too long after ABI released BigDye™ V1.1 & v3.1 for Sanger Sequencing.

BetterBase is a novel enhancing buffer specially designed and tested for use with the ABI BigDye™ (Versions 1.1 & 3.1). It is compatible with all Sanger Sequencing systems (eg: the ABI, MegaBACE and Beckman Sanger sequencing systems). The buffer can provide greatly improved results with difficult templates.

It’s easy to use:

  • Dilute the BigDye in BetterBase at 1 in 6, 1 in 12, 1 in 15 or higher.
  • The choice of dilution is dependent on size, quantity and quality of the DNA template.
  • As always, we are happy to assist where needed.

BigDye is a registered Trademark of Applied Biosystem

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At Microzone, we recognise the unique demands of every laboratory. Whether you're ramping up experiments or seeking specialised formulations, our dedicated team is on standby. Contact us today and benefit from personalised attention that ensures your order is precisely tailored

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Why Microzone?

Since 1998, Microzone has been at the forefront of empowering scientists in their DNA & RNA research. Our legacy is built on a comprehensive suite of products tailored for DNA/RNA extraction, purification, amplification, post-PCR clean-up, and sequencing. From PCR, qPCR, RT-qPCR, and HRM tools to advanced solutions like magnetic bead extraction and direct-to-PCR extraction buffers, we've consistently delivered precision and reliability. Choose Microzone, and harness two decades of expertise dedicated to advancing molecular biology.