Welcome BetterBuffer – the next evolution in enhancing buffers, meticulously conceptualized by Microzone. Tailored with precision and designed to infuse clarity into every sequencing run, BetterBuffer bridges the gap between performance and affordability. Exclusively fashioned for ABI BigDye sequencing mixes v1.0 and 3.0, this buffer stands out, promising unwavering consistency and top-tier results, while remaining user-friendly and sustainable.

  • Advanced enhancing buffer exclusively for ABI BigDye sequencing mixes v1.0 and 3.0
  • Universal adaptability: Fits seamlessly with all sequencing machines, excluding MegaBASE
  • Facilitates effortless ABI BigDye dilution, optimizing product longevity
  • Crafted to reduce sequencing costs without compromising on outcome quality


  • Get more tests from your BigDye™ and save money
  • Increases sanger sequencing signal
  • Simple and easy to use
  • Use with Sanger Sequencing
  • Sequence enhancer
  • BigDye™ dilution buffer

Microzone’s BetterBase was released not too long after ABI released BigDye™ V1.1 & v3.1 for Sanger Sequencing.

BetterBuffer is a sequence enhancer and BigDye™ (Versions 1.0 & 3.0) dilution buffer and is compatible with ABI sequencing machines (apart from MegaBACE).

It’s easy to use:

  • Dilute the BigDye in BetterBase at 1 in 6, 1 in 12, 1 in 15 or higher.
  • The choice of dilution is dependent on size, quantity and quality of the DNA template.
  • As always, we are happy to assist where needed.

BigDye is a registered Trademark of Applied Biosystem

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At Microzone, we recognise the unique demands of every laboratory. Whether you're ramping up experiments or seeking specialised formulations, our dedicated team is on standby. Contact us today and benefit from personalised attention that ensures your order is precisely tailored

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Why Microzone?

Since 1998, Microzone has been at the forefront of empowering scientists in their DNA & RNA research. Our legacy is built on a comprehensive suite of products tailored for DNA/RNA extraction, purification, amplification, post-PCR clean-up, and sequencing. From PCR, qPCR, RT-qPCR, and HRM tools to advanced solutions like magnetic bead extraction and direct-to-PCR extraction buffers, we've consistently delivered precision and reliability. Choose Microzone, and harness two decades of expertise dedicated to advancing molecular biology.